Mevalonate biosynthesis pathway regulates the development and survival of brown adipocytes
Summary: The high thermogenic activity of brown adipose horn tissue (BAT) has received considerable attention.Here, we demonstrated the role of the mevalonate (MVA) biosynthesis pathway in the regulation of brown adipocyte development and survival.The inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the rate-limiting enzyme in the MV